The crash occurred just before 4:30 a.m. on State Route 53 near the intersection of State Route 281.
The Tennessee Highway Patrol said Janis Ann Smith and her passenger crashed into Redena Murdock’s car.
Murdock was trying to turn onto SR 281 and didn’t see the other car coming, said THP.
Smith and her passenger were taken by helicopter to the hospital. Paramedics took Murdock and a 14-year-old passenger by ambulance to Cannon County Hospital.